Brief Overview

Recreational drug users dread LSD being declared as illegal. Therefore, scientists have come up with a new research chemical by attaching a propionyl group to the indole of LSD (Lysergic acid Diethylamide). . This new legal high is known as 1P-LSD (1-Propionyl-Lysergic acid Diethylamide). It first hit the online market in January 2015. Analogous and homologous to LSD and ALD-52 respectively, 1P-LSD is a psychedelic of lysergamide class and is being studied in order to bypass drug laws. It is a new designer drug and a legal stimulant. Its indole group has a propionyl group attached to its nitrogen. Being sold as a designer drug, 1P-LSD 38% as potent as LSD with a shorter duration of action.

1P-LSD; A prodrug for LSD?

Scientists regard 1P-lLSD as a prodrug for LSD because when it is incubated in human serum, 1P-LSD metabolizes to produce detectable levels of LSD. Therefore, it is thought to act in part for LSD. This also means that LSD is the active component of 1P-LSD and accounts for most of the effects produced by it.

Mechanism of action of 1P-LSD

1P-LSD is thought to exert its effects via two mechanisms.

1- Serotonergic stimulation

1P-LSD is classified as a serotonergic hallucinogen because it exerts its effects via serotonergic 5HT2A receptors in the brain. However, instead of directly binding to these receptors, 1P-LSD is first converted to Lysergic acid diethylamide in human serum which then binds the serotonergic receptors and acts as a partial agonist. Serotonin is a very important hormone and a potent stimulator of brain function and mood.

2- Monoamine pathway

According to some studies, 1P-LSD binds to monoamine receptors.  These receptors are similar to those for norepinephrine and dopamine, therefore, exerting similar effects.

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